Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice
J. Clin. Invest. Meilin Wu, et al. 118:2076 doi:10.1172/JCI33715 [Go to this article.]

Figure 2
Persistent expression of Pax3 rescues Pax3-null defects. (A) E13.5 littermates resulting from Pax3^Cre/+, R26^Pax3/+ intercrosses are shown. Note the open neural tube and exencephaly in the Pax3^Cre/Cre, R26^+/+ embryo (arrows, upper right panel) that are rescued in the embryos persistently expressing Pax3 (lower panels). (B) H&E-stained sagittal sections of E17.5 littermates show the diaphragm (arrows), which is thin and lacking muscle in Pax3^Cre/Cre, R26^+/+ embryos (upper right panel) but restored in the embryos persistently expressing Pax3 (lower panels). Original magnification, ×6.3.